“QT clock” to improve detection of QT prolongation in long QT syndrome patients

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"QT clock" to improve detection of QT prolongation in long QT syndrome patients.

BACKGROUND The QT interval is a risk marker for cardiac events such as torsades de pointes. However, QT measurements obtained from a 12-lead ECG during clinic hours may not capture the full extent of a patient's daily QT range. OBJECTIVE The purpose of this study was to evaluate the utility of 24-hour Holter ECG recording in patients with long QT syndrome (LQTS) to identify dynamic changes in...

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KCNE1 and KCNE2 variants in Patients with Long QT Syndrome

Introduction: Long QT syndrome (LQTS) is a type of ventricular arrhythmia characterized by prolonged QT intervals on electrocardiogram or delay in ventricular repolarization and it can lead to syncope, seizure and sudden cardiac death. Here, KCNE1 and KCNE2 variants are studied among Iranian affected families with this syndrome. Materials and Methods: Fifty patients referring to Rajaei Cardiov...

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Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans.

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Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes.

AIMS CACNA1C mutations have been reported to cause LQTS type 8 (LQT8; Timothy syndrome), which exhibits severe phenotypes, although the frequency of patients with LQT8 exhibiting only QT prolongation is unknown. This study aimed to elucidate the frequency of CACNA1C mutations in patients with long QT syndrome (LQTS), except those with Timothy syndrome and investigate phenotypic variants. METH...

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ژورنال

عنوان ژورنال: Heart Rhythm

سال: 2016

ISSN: 1547-5271

DOI: 10.1016/j.hrthm.2015.08.037